Specifically, the deposit of cholesterol occurs in the cell membrane in lipid rafts, which could activate signaling pathways related to the development of this type of cancer [55] and decrease the expression of the PTEN tumor suppressor gene, activating the pathway of PI3K-AKT-mTOR, related to high-grade prostate cancer [56]. The gene discussed is AKT1; the disease is Familial prostate cancer.