Other AML Supertargets encoded SPI1 (SPI1 proto-oncogene, a.k.a. PU.1), LIM domain only 2 (LMO2), Janus kinase 2 (JAK2), and growth factor independence 1 (GFI1) proteins (Figure 1A). This evidence concerns the gene GFI1 and acute myeloid leukemia.