In non-Hodgkin’s lymphoma (NHL), four out of five Supertargets (myocyte enhancer factor 2B (MEF2B), EBF transcription factor 1 (EBF1), BCL6 transcriptional repressor (BCL6), and paired box 5 (PAX5)) encode well-studied transcription factors with significant roles in B-cell malignancies (reviewed in [37]) (Figure 3A). The gene discussed is MEF2B; the disease is non-Hodgkin lymphoma.