SOS1 and chronic myelogenous leukemia, BCR-ABL1 positive: Furthermore, three CML Supertarget genes, that is, GRB2-associated binding protein 2 (GAB2), son of sevenless homolog 1 (SOS1), and signal transducer and activator of transcription 5B (STAT5B), are the components of JAK/STAT signaling pathway critical in BCR-ABL1-positive neoplasms [31,32,33,34].