The LEF1 (lymphoid enhancer binding factor 1), RUNX1 (RUNX family transcription factor 1), and EBF1 (EBF transcription factor 1) genes, identified as ALL Supertargets, are key hematopoietic transcription regulators that play central roles in differentiation and survival of lymphocyte progenitors [28] (Figure 1A). This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.