Interestingly, high glucose concentrations treatment lowered the protein expression levels of NRF2, HO-1, and γ-glutamyl cysteine synthetase (γ-GCS) demonstrating that high glucose levels inhibit NRF2/KEAP1 signaling pathway in prostate cancer cells, increasing the content of ROS promoting the apoptosis of prostate cancer cells [135]. This evidence concerns the gene HMOX1 and Familial prostate cancer.