TP53 and cancer: Similarly, among four distinct gastric tumor subgroups previously defined by the Asian Cancer Research Group (ACRG), MSI, MSS/EMT, MSS/TP53+ (MSS with intact TP53 activity), and MSS/TP53- (MSS with TP53 functional loss), MSI- and MSS/TP53--type tumors could be stratified into significantly different prognostic groups based on SU–SD classification (Supplementary Figure S15).