VEGFA and colorectal cancer: In the “VEGF trap (aflibercept) with irinotecan in colorectal cancer after failure of oxaliplatin regimen trial” (VELOUR trial), the combination of Ziv-Aflibercept with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) was studied in patients with mCRC, previously treated with oxaliplatin, including those previously treated with bevacizumab [33].