Tumor cells spread through the cell adhesion molecule L1 (L1CAM) and activate the mechanotransduction effectors Yes-associated protein (YAP) and myocardin-related transcription factor (MRTF) by engaging integrin β1 and integrin-linked kinase (ILK), L1CAM and YAP signaling, enabling the outgrowth of metastasis-initiating cells [307]. The gene discussed is ILK; the disease is neoplasm.