The release of extracellular DNA and proteins, a process mediated by the enzyme peptidyl arginine deiminase 4 (PADI4) and translocation of elastase to the nucleus, activates tumor-associated fibroblasts in another model, that of pancreatic stellate cells, and inhibits stromal activation that promotes cancer cell proliferation and metastasis [365]. Here, PADI4 is linked to neoplasm.