IL6 and neoplasm: Type II inflammation, mediated by IL-11, IL-22, IL-33, IL-6/membrane IL-6 receptor α (mIL-6 Rα) and cell-mediated immune response through CD4+ Th2 cells, which produce IL-12, M2 macrophages, and group 2 innate lymphoid cells (ILC-2), induces classic anti-inflammatory signaling and tumor relapse [209].