- switch in MSCs differentiation potential from osteogenic to adipogenic, - TGFβ/BMP, PPARγ2 signaling,- Ob-R, FABP4, JAK/STAT3, PI3K/Akt, ERK, Rho/ROCK, Notch,TNF-α, ERK, NF-kB, IL-1β, CREB, IL-6, resistin - ligand-independent ER and Her2 receptor activation - CD36 cysteine oxidation - P450 epoxygenase- induced epoxyeicosatrienoic acid synthesis- Promotes ER+ and ER− BC cell proliferation, motility and metastasis- Hif1α. Here, ESR1 is linked to breast cancer.