IL-6, IL-8, Il-1b, Il-6, Il-27, Il-1f9, CCl4, Ccl5, Tnfsf14, Ltb, TGF-β1 signaling, SMAD2 and 3,- CD133+ cancer cell renewal- IL-6/Notch induced endocrine resistance through gp130/gp80, STAT3, VEGF, PI3K/Akt signaling, EGFR and ERK. The gene discussed is IL6R; the disease is cancer.