PIK3CA and breast cancer: Fatty acid-binding protein (FABP)4 is internalized by BC cells and enhances JAK/SATA3, PI3K/Akt, and MAPK/ERK signaling, visfatin stimulates MAPK/ERK and Notch signaling, and chemerin upregulates RhoA/ROCK activation via its chemokine-like receptor (CMKLR)1 [255].