Mature adipocytes also release extracellular vesicles that promote breast cancer cell malignancy by enhancing growth, motility, invasion, EMT traits and stem cell-like properties in both ER+ and triple-negative BC in vitro, and aid breast tumor cells in lung metastatic colonization in vivo in tail vein-injected cells in a murine model in a hypoxia-inducible factor (HIF)-1α-dependent manner [269]. The gene discussed is ESR1; the disease is breast carcinoma.