- Elevated perioperative IL-6, IL-8, NF-kB, CRP- reduced IRF1 - promotes growth of micrometastases- increases GATA-1 GATA-2, EGR3, STAT3 activity- increased tumor-infiltrating monocytes- decreased tumor-infiltrating B cells - perioperative decline in stimulated IL-12- perioperative decline in IFNγ, mobilization of CD16− monocytes- decreased expression of CD11a on circulating NK cells. The gene discussed is IRF1; the disease is neoplasm.