Wnt5a non-canonical Wnt signaling induces dormancy in prostate cancer cells in vitro and in vivo in the BM osteoblast niche in a reversible manner via receptor tyrosine kinase-like orphan receptor 2 (ROR2)-activation of siah E3 ubiquitin protein ligase 2 (SIAH2) expression, which represses canonical Wnt/β-catenin tumor stem cell and tumor progression signaling [142]. This evidence concerns the gene WNT5A and Familial prostate cancer.