For example, ANKS1A regulates the stability and recycling of EGF receptor [58], the degradation of EphA8 and EphA2 in mouse embryonic fibroblast [59], and COPII-mediated anterograde transport of EphA2 and ErbB2 in a colon carcinoma cell line [60]. The gene discussed is EPHA2; the disease is colon carcinoma.