Several proteins in the PI3K/AKT pathway were found to be upregulated in activin (+) AOIs in the tumoral compartment, including PLCG1, Phospho-PRAS40, and Phospho-Tuberin, suggesting a possible switch to non-canonical PI3K/AKT signaling in tumor cells (Figure 6A–C). The gene discussed is PLCG1; the disease is neoplasm.