Per the WHO, a diagnosis of AML may be made for certain abnormalities irrespective of blast percent; these include PML::RARA, AML with RUNX1::RUNX1T1 and AML with CBF::MYH11, in addition to mutations in NPM1 and biallelic (biCEBPA) or single mutations located in the basic leucine zipper (bZIP) region of the gene (smbZIP-CEBPA). The gene discussed is NPM1; the disease is acute myeloid leukemia.