MMP9 and cancer: Univariate analyses revealed that the depth of invasion (p < 0.001), lymphatic vessel invasion (p = 0.001), blood vessel invasion (p = 0.030), pathological stage (p < 0.001), infiltration of CD68 (p = 0.009), CD163 (p = 0.049), and CD204 (p = 0.002) positive macrophages, and cancer nest MMP9 positivity (p = 0.038) were significantly correlated with patient poor disease-free survivals (Table 2).