Another study described indirect co-culture using SKOV3 (ovarian carcinoma) cells and THP-1 derived macrophages highly enhanced IL-8 levels in the co-culture supernatant, which lead to Stat3 phosphorylation and then polarized macrophages into an M2-like phenotype and induced stem cell-like features in cancer cells [37]. The gene discussed is CXCL8; the disease is cancer.