In a multivariable analysis of a cohort of 241 younger adult patients aged 18–60 years with FLT3-ITD-mutated AML, a non-JMD FLT3-ITD located in the β1-sheet of the TKD1 was shown to be an unfavorable prognostic factor for achieving CR after induction therapy as well as for RFS and OS after allogeneic hematopoietic stem cell transplantation (HSCT) [5]. Here, FLT3 is linked to acute myeloid leukemia.