TP53 and neoplasm: Curcumin shows effects on miRNAs: it inhibits oncogenic ones, such as miR-21 and miR-186, and downregulates cyclin D1, cyclin E and mouse double minute 2 homolog (MDM2), while upregulating tumor suppressors, such as miR-15, miR-16, miR-22, retrovirus 27a, miR-34, miR-22, P21, p27 and p53.