GSTM1 and colorectal neoplasm: Furthermore, TTI-101 treatment also led to the upregulation of important genes such as GUCA2A, CDX2, VDR, GSTM1, HPGD, and PPARG that have been shown by others to be associated with the prevention of large intestine neoplasms [53,54,55,56,57,58,59].