TP53 and cancer: Table 3 reports DNA genes studied in EVs. In 2013, one of the first studies reported the presence of genomic and mitochondrial DNA in human plasma EVs, and in 2014, mutant KRAS and TP53 DNAs were found in serum EXOs collected from cancer patients [24,127]. Moreover, recent findings have shown that horizontal transfer of mitochondrial DNA can occur through EVs. In detail, mitochondrial DNA carried within EVs has been found to promote the reactivation of dormant cancer stem-like cells, resulting in resistance to endocrine therapy [128].