Ubiquitously expressed in different tissue types, EGFR is also one of the receptors found to be altered in several cancers, particularly breast, non-small cell lung cancer (NSCLC), glioblastoma (GBM), head and neck squamous cell carcinoma (HNSCC), ovarian, and melanoma [44,45,46,47,48,49]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.