One case report found that combined therapy with nab-paclitaxel and Pembrolizumab incited a remarkable recovery in a triple-negative spindle-cell MBC patient with previously treated metastatic disease and overexpression of PDL-1, indicating that specific combinations of chemotherapy and immunotherapy may be more efficacious based on molecular and histological features of disease [50]. This evidence concerns the gene CD274 and metastatic neoplasm.