IMbrave 050 (NCT04102098) is one of the most interesting, randomized, open-label phase III trial, launched at the beginning of 2020 with the purpose to evaluate the effect of dual PD-L1/VEGF blockade using atezolizumab plus bevacizumab in high-risk HCC after curative resection or ablation [87]. This evidence concerns the gene CD274 and hepatocellular carcinoma.