Considering that hepatitis activity and liver fibrosis are risk factors for HCC, we added serum alanine aminotransferase (ALT), serum bilirubin levels, platelet counts, elongation of prothrombin time, and the cirrhosis etiologies of hepatitis B virus (HBsAg) and antibodies against hepatitis C virus to the original propensity score matching (shown in Supplementary Table S2). The gene discussed is F2; the disease is Cirrhosis.