NSD1 and acute myeloid leukemia: The novel ELN 2022 recommendations for diagnosis and management of AML in adults now recognize three different AML subtypes defined by NUP98-rearrangements, two defined by specific fusions (::NSD1 and ::KDM5A) and one defined by NUP98-rearrangements other than NSD1 or KDM5A [1].