These may represent subgroups with distinct biological functions and are potentially directly targetable, as has been shown for the PHD of the NUP98::PHF23 oncoprotein in AML cell lines through disulfiram, a drug currently used for the treatment of chronic alcohol abuse, as it inhibits the PHD-containing acetaldehyde dehydrogenase needed for alcohol metabolism [71,72,73,74]. The gene discussed is PDC; the disease is acute myeloid leukemia.