Recurrent rearrangements at 11q15.4 involving the gene Nucleoporin 98 and 96 precursor (NUP98) are found in a variety of hematologic neoplasias, such as AML, myelodysplastic neoplasias (MDS), and T-cell acute lymphoblastic leukemia (T-ALL) [4,5]. The gene discussed is NUP98; the disease is acute lymphoblastic leukemia.