Different from the mouse breast cancer model, the majority of ATX in human breast tumors was expressed by endothelial cells and a small portion of fibroblasts (Figure 3B,C), whereas LPA receptors in the tumors were widely expressed by cancer cells, fibroblasts, T cells, myeloid cells, and endothelial cells (Figure 3C). The gene discussed is ENPP2; the disease is breast carcinoma.