KRAS and colorectal carcinoma: In contrast, an unsupervised clustering analysis of mRNA gene expression data from 443 CRC patients revealed six subgroups: (C1) CIN with downregulated immune pathways, (C2) mismatch repair, (C3) KRAS-mut, (C4) cancer stem cell, (C5) CIN with Wnt pathway upregulation and (C6) CIN with a normal-like expression profile [109].