In addition, a comparison of cancer-specific DNA methylation between African American and Caucasian CRC patients identified DNA hypermethylation of ARHGEF4, CHL1, CHL4, GDF, ITGA4, NELL and several microRNAs including miR-9-3p and miR-124-3p in African American CRC patients [108]. Here, ARHGEF4 is linked to colorectal carcinoma.