It should be noted that SDC2 DNA methylation testing in stool samples is approved in Korea (EarlyTect-Colon Cancer) and China (Colosafe) for CRC detection, and a yet unapproved test described as ColoDefense includes screening for both SDC2 and SEPT9 DNA methylation (reviewed in [58]). The gene discussed is SDC2; the disease is malignant colon neoplasm.