(7) Bisulfite pyrosequencing of CDH1, CDH13, CDKN2A (p16), CDKN2A (p14), ESR1, HPP1, MGMT, MINT1, MINT2, MINT31, MLH1, THBS1 and TIMP3 across paired primary tumor-liver metastasis pairs, as well as CRCs with or without metastases, showed stochastic variability as a function of metastasis and suggest that cancer-specific DNA changes mostly occur prior to metastasis [88], which is in agreement with the other reports. This evidence concerns the gene CDKN2A and cancer.