In pooling data for over 5000 CRC patients, Phipps et al. [76] categorized CRCs into five groups based on their molecular profiles: (1) CIMP-positive, BRAF mutant (BRAF-mut), KRAS wild-type (KRAS-wt), high microsatellite instability (MSI-H); (2) CIMP-positive, BRAF-mut, KRAS-wt, microsatellite stable (MSS) or low microsatellite instability (MSI-low); (3) CIMP-negative, BRAF-wt, KRAS-mut, MSS/MSI-low; (4) CIMP-negative, BRAF-wt, KRAS-wt, MSS/MSI-low; and (5) CIMP-negative, BRAF-wt, KRAS-wt, MSS/MSI-low. Here, KRAS is linked to colorectal carcinoma.