We observed significant associations between the risk of liver cancer and three cytokines: interleukin-23 receptor (OR = 0.60, 95% CI 0.38–0.95, p = 0.028), interleukin-27 receptor subunit alpha (OR = 1.16, 95% CI 1.01–1.13, p = 0.036), and C-X-C motif chemokine 16 (OR = 0.78, 95% CI 0.61–1.00, p = 0.046) (Figure 5; Supplementary Table S3). The gene discussed is IL27RA; the disease is liver cancer.