Kaur et al. used ML and large-scale transcriptomic profiling data from 2316 HCC and 1665 nontumorous tissue samples to identify three platform-independent diagnostic genes—FCN3 (downregulated in HCC), CLEC1B (downregulated in HCC), PRC1 (upregulated in HCC)—that were able to detect HCC in both training and validation datasets with good accuracy (93–98%) and show prognostic potential [22]. The gene discussed is PRC1; the disease is hepatocellular carcinoma.