Gholizadeh et al. also studied mRNAs via machine learning to develop a screening program differentiating normal tissue from HCC tissue, resulting in three diagnostic biomarkers (CYP2E1, ARK1C3, AFP) and four additional prognostic markers (SOCS2, MAGEA6, RDH16, RTN3) [25]. The gene discussed is AFP; the disease is hepatocellular carcinoma.