While one of the isomers of argininosuccinate synthase (ASS1) is slightly increased (FC = 1.06 (95% CI 1.03–1.09), see Figure 8C), the down-regulation of argininosuccinate lyase (ASL) (FC = −1.24 (95%CI −1.33 to −1.15), see Figure 8D) may decrease the generation of fumarate, which is needed for mitochondrial metabolism and thus pushes the cancer cell from aerobic to anaerobic metabolism. Here, ASS1 is linked to cancer.