ASL and cancer: While one of the isomers of argininosuccinate synthase (ASS1) is slightly increased (FC = 1.06 (95% CI 1.03–1.09), see Figure 8C), the down-regulation of argininosuccinate lyase (ASL) (FC = −1.24 (95%CI −1.33 to −1.15), see Figure 8D) may decrease the generation of fumarate, which is needed for mitochondrial metabolism and thus pushes the cancer cell from aerobic to anaerobic metabolism.