Our data suggested that, in CRC, the up-regulation of carbamoyl phosphate synthase 1 (CPS1) (FC = 1.56 (95% CI 1.16–2.10), see Figure 8A) might help cancer cells to convert the toxic NH4 to carbamoyl phosphate (CP) that could be utilized for pyrimidine synthesis for growth and proliferation. This evidence concerns the gene CPS1 and cancer.