SRSF6 may stimulate or diminish EMT, depending on the cancer type: in colorectal cancer, downregulation of long non-coding RNA LINCO1133 by TFGβ leads to an increased pool of free SRSF6 and stimulation of EMT [171]; in pancreatic cancer, SRSF6 inhibits this process, while increased expression of miR-193a-5p reduces SRSF6 levels, enabling EMT [172]. Here, SRSF6 is linked to pancreatic neoplasm.