IQGAP1 and head and neck cancer: IQGAP1 (IQ motif-containing GTPase-activating protein 1) that scaffolds different signaling pathways important in oncogenesis (including RAS and PI3K) and involving many kinases, mediates phosphorylation of SRSF6 and other splicing factors in head and neck cancer cells as well as in normal keratinocytes [175].