Linear dodecapeptide peptide (BRBP1)-functionalized cholesterol- and distearoylphosphatidylcholine (DSPC)-based liposomes were developed to deliver paclitaxel and siRNA specific to the drug-resistant gene twinfilin-1 (TWF1) in TNBC tumor xenografts and in a brain metastatic mouse model (231-BR) [95]. The gene discussed is TWF1; the disease is neoplasm.