Furthermore, cancer-specific epigenetic changes such as silencing of Achaete-Scute Homolog (ACLS2) [96] or increasing the levels of lncRNA sponges such as MAPKAPK5 Antisense RNA 1 (MAPKAPK5-AS1) [94], circular RNA protein tyrosine kinase 2 (circPTK2) [115], circLIFR [116] or metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) [99,117] that limit the miR-200 family expression, were also shown to correlate with an increased metastatic potential. This evidence concerns the gene MALAT1 and cancer.