In vitro, glioma conditioned media upregulates Nrf2 expression in DC and diminishes their maturity as measured by CD80 and CD86 expression, repeating observations made by Kikuchi et al. These glioma conditioned DC showed additional signs of tolerogenic character as indicated by reduced IL-12 and increased IL-10 cytokines present in culture supernatant. Here, IL10 is linked to central nervous system cancer.