While these studies provide strong evidence for DC-mediated antigen trafficking to draining lymph nodes, it is interesting to note that there is also a small population of CD8a+CD103+ LN resident cDC1 that takes up fluorescent tumor antigens, leaving open the possibility that tumor antigen uptake by LN resident DC can contribute to the antitumor response [50]. Here, MPPE1 is linked to neoplasm.