To confirm the key role of the identified orthologs (K08291, K01535, and K11783) that correlated with oral microbiota in the cancer group and determine the effect of oral microbiota alteration on immune homeostasis, inflammation, cancer initiation, we measured the concentrations of TNF-α, induced protein 8 (TNFAIP8/TIPE), and IL-6, which are cytokines associated with these orthologies. The gene discussed is TNF; the disease is cancer.