We performed survival analysis using the TCGA PAAD cohort for each of these genes and found statistically significant differences in twenty-eight genes (IFI27, IL1R2, IL1RN, IL1RAP, IL18, IL22RA1, HCP5, SLFN13, CD58, CD109, IFI44L, IFI16, IFITM1, IFIT1, IFIT3, IRF9, IFIT2, IFI35, CXCL10, CXCL5, CXCL9, S100P, S100A6, S100A2, S100A16, S100A11, S100A14, and S100A10), which shared a pattern: a higher expression in patients associated with a lower rate of survival. Here, CD58 is linked to pancreatic adenocarcinoma.