VCAN and neoplasm: We noted the presence of genes encoding ECM components (e.g., collagens, fibronectin, laminin, and stratifin), proteoglycans (e.g., versican), cell adhesion molecules, integrins, matrix metallopeptidases, and additional peptidases and enzymes that impact mechano-contractility, epithelial tension, and the stiffness of the tumoral stroma, which can promote tumor progression and resistance to therapy (Figure 4).