ERBB2 and neoplasm: HER2, which plays a key role in tumor growth by activating different signaling pathways closely linked to cell proliferation, can be targeted with Trastuzumab (Herceptin, Roche Registration GmbH, Grenzach-Wyhlen, Germany) and pertuzumab (Perjeta, Roche Registration GmbH, Germany), which are two monoclonal antibodies that inhibit HER2 through the extracellular domain of the receptor [46], thereby blocking the signaling pathways it controls, and thus, exerting a considerable antitumor effect [47].