The eighth edition of the American Joint Committee on Cancer, announced in 2017 and globally adopted on 1 January 2018, also integrated biomarkers such as tumor grade, hormone receptor status, expression of the human epidermal growth factor receptor (EGFR) family member HER2 (Human Epidermal Growth Factor Receptor 2/ErbB2 receptor tyrosine kinase 2) or multigene panel status for certain sub-groups, resulting in different prognostic stages for tumors with virtually identical histologic types [18]. Here, ERBB2 is linked to neoplasm.