Because of the strong positive correlation between fibrosis severity and the expression of CD3D (r = 0.62, p < 0.001); CD3E (r = 0.51, p < 0.001); and CD3G (r = 0.47, p < 0.001) (Supplementary Table S3) and the strong performance of CD3D in predicting fast liver fibrosis progression in patients with F1/F2 (Figure 4B), we evaluated the distribution of T cells using a mIF panel including antibodies against CD3, CD8, PD1, FOXP3, and CD45RO (Figure 5). The gene discussed is CD3E; the disease is Hepatic fibrosis.