The receiver operating characteristic curve (ROC) of [Tissue inhibitor of metalloproteinases-2 (TIMP-2)] × [insulin-like growth factor-binding protein 7 (IGFBP7)] measured at 4 h after admission to the intensive care unit (ICU) was 0.80 (95% CI: 0.68–0.91) for AKI development and 0.83 (95% CI: 0.69–0.96) for stage 2–3 AKI. The gene discussed is IGFBP7; the disease is acute kidney injury.