A retrospective Japanese study of 2923 patients showed that BNP (66.4 ± 56.3 vs. 44.0 ± 35.3 pg/mL, p < 0.01) and C-reactive protein levels (0.99 ± 1.56 vs. 0.18 ± 0.27 mg/dL, p < 0.01) were significantly elevated in cancer patients comparing to the non-cancer patients, probably due to cancer-related inflammation [50]. The gene discussed is NPPB; the disease is cancer.