For instance, we mention a 63-year-old female with an initial diagnosis of adenocarcinoma of the colon and stomach, which was diagnosed with liver metastasis of high-grade NEN originating from a gastric remnant; she had an LS-germline MLH1 mutation, in addition to the loss of MLH1 protein in NEN and adenocarcinoma of the stomach [67]. This evidence concerns the gene MLH1 and gastric adenocarcinoma.