Another unusual case of a 56-year-old women with LS harboring both MSH2 and MSH6 mutations included the onset of the pituitary tumor with apoplexy, and panhypopituitarism was followed by self-remission, and two years later, recurrence was confirmed with the identification of an undifferentiated pituitary carcinoma with pulmonary and osseous spreading [91]. The gene discussed is MSH6; the disease is panhypopituitarism.