Studies showed that the risk factors for DME [21] include hyperglycemia, duration of diabetes, hypertension, hyperlipidemia, renal dysfunction, pregnancy, the level of cytokine VEGF, heredity, etc. Additionally, other factors such as a history of cataract surgery, insulin use, sleep apnea syndrome, anemia, and ocular inflammation were also identified. Here, VEGFA is linked to Hyperglycemia.