Therefore, the aim of the present systematic review is to provide a more granular picture of post-acute COVID-19 musculoskeletal manifestations of rheumatological interest, with particular attention to: (1) joint pain; (2) new onset of rheumatic musculoskeletal diseases including RA, spondyloarthritis, PMR, gout, myositis and fibromyalgia; (3) presence of autoantibodies related to inflammatory arthritis such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA). This evidence concerns the gene PRTN3 and rheumatoid arthritis.