In erythroid differentiation, core transcriptional networks play crucial roles, which include gata binding protein 1 (GATA1), T-cell acute lymphoblastic leukemia/stem cell leukemia (TAL1/SCL), Krüppel-Like Factor 1 (KLF1), LIM domain only 2 (LMO2), and LIM domain binding protein 1 (LDB1) (Figure 4). Here, GATA1 is linked to acute leukemia.