The authors demonstrated that NPM1 -mut blocks the degradation of the RASGRP3 protein through binding to the ubiquitin ligase E3 MID1 protein, leading to RASGRP3 overexpression, as well as promoting the downstream activation of EGFR-STAT3, which in turn promoted proliferation and autophagy in AML cells [150]. This evidence concerns the gene NPM1 and acute myeloid leukemia.