RUNX1 and acute myeloid leukemia: Acute myeloid leukemia with core binding factor (CBF-AML) is characterized by the presence of t(8;21) (q22; q22), or inv (16) (p13q22)/t(16;16), which leads to the formation of RUNX1/RUNX1T1 (AML1/ETO) and CBFbeta-MYH11, respectively [133].