Recent advances in bioinformatics have enabled the identification of several epigenetic mutations affecting AML, including IDH1/2, Tet methylcytosine dioxygenase 2 (TET2), DNA methyltransferase 3A (DNMT3A), and ASXL1, all of which are associated with the pathogenesis of AML [163,164,165]. Here, DNMT3A is linked to acute myeloid leukemia.