NFE2L2 and pulmonary arterial hypertension: The authors also reported an increase in ROS levels in labyrinth placentas of NRF2−/− PAH mice accompanied by a low NAD(P)H dehydrogenase quinone 1 (NQO1) and sulfiredoxin 1 (SRXN1) expression, two NRF2 downstream genes, in these placentas.