Furthermore, neurons lacking AKAP1 showed reduced DRP1 S637 phosphorylation and experienced Ca2+ dysregulation [18].This study suggests that AKAP1/PKA inhibits DRP1-dependent mitochondrial fission, protecting neurons from ischemic stroke by sustaining respiratory chain activity, reducing superoxide production, and delaying Ca2+ dysregulation [18]. The gene discussed is DNM1L; the disease is ischemic stroke.