IL-6 was significantly increased in the serum samples of Peli1−/− (706.8 ± 43 vs. 259.7 ± 18.70; pg/mL; n = 6; p < 0.0001) and CP1KO (503.3 ± 10.59 vs. 259.7 ± 18.70; pg/mL; n = 6; p < 0.0001) sepsis groups when compared to the AMPELlTg/+ group. The gene discussed is IL6; the disease is Sepsis.