Similarly, serum TNF-α level was found to be significantly reduced in the AMPEL1Tg/+ sepsis group compared to the WTCLP (86.89 ± 14.36 vs. 161.8 ± 20; pg/mL; n = 6; p = 0.04), Peli1−/− (86.89 ± 14.36 vs. 260.4 ± 39.04; pg/mL; n = 6; p < 0.0001), and CP1KO (86.89 ± 14.36 vs. 221.4 ± 17.77; pg/mL; n = 6; p = 0.0010) sepsis groups. This evidence concerns the gene PELI1 and Sepsis.