In addition, TRPA1-deleted mice did not develop mechanical and cold allodynia in other models of neuropathic pain, including chemotherapy-induced peripheral neuropathy [38] and complex regional pain syndrome [15] Furthermore, the development of periorbital mechanical allodynia by the constriction of the infraorbital nerve was also attenuated following TRPA1 deletion [32]. This evidence concerns the gene TRPA1 and complex regional pain syndrome.