TRPV1 and atopic eczema: In an atopic dermatitis mouse model, the house dust mite (HDM) Dermatophagoides farinae stimulates transient receptor potential vanilloid type 1 (TRPV1+) sensory neurons in the skin to secrete SP, which triggers the activation and degranulation of the nearby mast cells by binding to MRGPRB2, thereby inducing atopic dermatitis (Figure 1) [72].