Mainly missense point mutations are found in diverse genes such as Superoxide Dismutase 1 (SOD-1), Transactive Response Deoxyribonucleic acid (DNA) Binding Protein (TAR-DNA-binding protein-43; TDP-43), Fused in Sarcoma (FUS)/ translocation in liposarcoma, and GGGGCC hexanucleotide repeat expansion in Chromosome 9 Open Reading Frame 72 (C9ORF72) gene, the latter accounting with 40–50% for the majority of fALS cases [2]. The gene discussed is SOD1; the disease is liposarcoma.