Overexpression of this intracellular Ang II fusion protein induced the expression of platelet-derived growth factor (PDGF) in rat hepatoma cells and activated cAMP response element-binding protein (CREB) activity in CHO-K1 and COS-7 cells [36,40], whereas global expression of ECFP/Ang II in mice led to elevated blood pressure and induced renal thrombotic microangiopathy [48]. The gene discussed is AGT; the disease is hepatocellular carcinoma.