AGT and Ureteral obstruction: These findings are somewhat unexpected and in contrast with previous studies showing that AT2 receptors mediated extracellular Ang II- and/or Ang III-induced natriuretic responses in the proximal tubules of the rat kidney in part by inducing the internalization of NHE3 from the apical membranes and Ang II-induced inflammatory responses in unilateral ureteral obstruction [23,27,50,51,52].