Focusing on genes already described to be involved in tumor development, progression, or repression of malignancies, and to be connected to the phenomenon of stemness in the broadest sense, we selected five promising genes associated with TMZ-promoted dormancy in GBM, namely CCRL1, SLFN13, SKI, Cables1, and DCHS1, for further validation. The gene discussed is SLFN13; the disease is glioblastoma.