Czech and colleagues in 2012 and 2014 demonstrated an increase in SRY expression in response to toxin-induced insults in male DA neurons and in a male neuroblastoma cell line [106,217], whereas Lee et al. (2019) correlated the reduction in SRY expression in toxin-induced rat models for PD (6-ODHA and rotenone models) with a decreased loss of DA neurons and with ameliorated motor defects. This evidence concerns the gene SRY and Parkinson disease.