The serum samples from the individuals with T2D and moderate albuminuria triggered a significant increase in pS313-PACSIN2 with a limited effect on total PACSIN2 or the ratio of pS313-PACSIN2 to total PACSIN2 when compared to podocytes treated with serum from individuals with T2D and normal albumin excretion rate (Figure 2I–L). This evidence concerns the gene ALB and type 2 diabetes mellitus.