To gain a comprehensive understanding of whether CKD regulates the secretory functions of vein vascular cells, we collected 2640 canonical secretome genes from the HPA [12]; 964 caspase-1-dependent noncanonical secretome genes [42]; 1223 caspase-4-dependent noncanonical secretome genes [43]; and 6560 exosome secretome genes from a comprehensive exosome database (http://www.exocarta.org, accessed on 20 December 2022) [44], as we have reported [40]. This evidence concerns the gene CASP4 and chronic kidney disease.