3.2. Chronic Kidney Disease Transforms Veins into an Immune Organ by Upregulating 13 Cytokine and Chemokine Genes, 36 Canonical Secretomes, 2 Caspase-1- and 5 Caspase-4-Dependent Noncanonical Secretomes, and 28 Exosome Secretomes. Here, CASP4 is linked to chronic kidney disease.