Additional changes in CKD veins include upregulation of genes involved in mitochondrial bioenergetics to induce immunometabolic reprogramming, over 20 fibroblast-enriched genes and fibrogenic factors, and numerous cell death/survival programs to shape the composition of immune cell types in veins, as well as reprogramming of protein kinase signal transduction pathways, including SRPK3 and CHKB. This evidence concerns the gene CHKB and chronic kidney disease.