SRPK3 and chronic kidney disease: Additional changes in CKD veins include upregulation of genes involved in mitochondrial bioenergetics to induce immunometabolic reprogramming, over 20 fibroblast-enriched genes and fibrogenic factors, and numerous cell death/survival programs to shape the composition of immune cell types in veins, as well as reprogramming of protein kinase signal transduction pathways, including SRPK3 and CHKB.