However, it is unknown whether CKD modulates the transcriptomic changes in vein vascular cells and increases the secretion of proinflammatory cytokines and chemokines, the canonical secretomes (secretory proteins with signal peptides), the caspase-1-dependent noncanonical secretomes, the caspase-4-dependent noncanonical secretomes, and exosome secretomes [13]. The gene discussed is CASP4; the disease is chronic kidney disease.