CASP4 and chronic kidney disease: Both canonical caspase-1 and noncanonical caspase-4/11 play a critical role in sensing pathogen-associated molecular patterns (PAMPs)/conditional damage-associated molecular patterns (DAMPs), mediating inflammatory cytokine secretion and cell death (pyroptosis), and accelerating CKD-promoted neointima hyperplasia [23,24,25,26,27,28] (Figure 3A).