In addition, CKD modulated the gene expression changes of 18 caspase-1-dependent noncanonical secretomes with two upregulated genes and 16 downregulated genes (Supplementary Table S3); and CKD differentially modulated the gene expression changes of 56 caspase-4-dependent noncanonical secretomes with 5 (8.92%) upregulated genes and 51 (91.07%) downregulated genes (Supplementary Table S4). Here, CASP4 is linked to chronic kidney disease.