CD8A and colorectal carcinoma: Other studies using in vivo mouse models showed that IL-33 promotes the function of CD8+ T cells and NK cells and, therefore, tumor eradication [76], suggesting that IL-33 signaling may play a protective role against CRC [77]; at the same time, however, its ability to induce cell migration in vitro hints at its involvement in metastasis development in vivo in CRC [73] (Figure 3a).