Different cellular types are then able to increase IL-33′s bioactivity: neutrophils, abundant in inflammatory environments, secrete cathepsin G, and serine proteases and elastase, which can cleave IL-33 to a ten-fold more powerful isoform; similarly, in allergic reactions, activated mast cells release chymase and tryptase proteases, which cleave IL-33 in thirty-fold more bioactive isoforms [5,23]. Here, IL33 is linked to allergic disease.